Thyroperoxidase Protein (His tag)
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- Target See all Thyroperoxidase (TPO) Proteins
- Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This Thyroperoxidase protein is labelled with His tag.
- Purpose
- Recombinant Human Thyroid peroxidase/TPO Protein (257 Ser/Ala, 725 Pro/Thr, His Tag)
- Sequence
- Met 1-Arg846, 257 Ser/Ala, 725 Pro/Thr
- Characteristics
- A DNA sequence encoding the human TPO (P07202-1) extracellular domain (Met 1-Arg846, 257 Ser/Ala, 725 Pro/Thr) was fused with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product TPO Protein
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Thyroid Peroxidase (TPO) (AA 19-846) protein (His tag)
TPO Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Thyroid Peroxidase (TPO) (AA 32-834) protein (His tag)TPO Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Thyroid Peroxidase (TPO) (AA 672-779) protein (GST tag)TPO Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Thyroid Peroxidase (TPO) (AA 1-933) protein (GST tag)TPO Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))
- Alternative Name
- Thyroid peroxidase/TPO (TPO Products)
- Synonyms
- MSA Protein, TDH2A Protein, TPX Protein, TPO Protein, msa Protein, tpx Protein, xtpo Protein, LOC100218312 Protein, thyroid peroxidase Protein, TPO Protein, Tpo Protein, tpo Protein, LOC100547103 Protein
- Background
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Background: Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. It used to be taken as the formerly so-called `microsomal antigen` several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx 100 kDa molecular weight. Thyroid peroxidase is an enzyme expressed abundantly in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of thyroxine or triiodothyronine, thyroid hormones. Thyroid peroxidase plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin to form precursors of the thyroid hormones T4 and T3.
Synonym: MSA,TDH2A,TPX
- Molecular Weight
- 93.8 kDa
- Pathways
- Thyroid Hormone Synthesis
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