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Thrombopoietin Protein (THPO) (His tag)

THPO Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Catalog No. ABIN7320657
  • Target See all Thrombopoietin (THPO) Proteins
    Thrombopoietin (THPO)
    Protein Type
    Recombinant
    Origin
    • 11
    • 10
    • 4
    • 3
    • 2
    • 2
    • 2
    Mouse
    Source
    • 23
    • 3
    • 2
    • 2
    • 1
    • 1
    Human Cells
    Purification tag / Conjugate
    This Thrombopoietin protein is labelled with His tag.
    Purpose
    Recombinant Mouse Thrombopoietin/TPO Protein (His Tag)
    Sequence
    Ser22-Thr356
    Characteristics
    Recombinant Mouse Thrombopoietin is produced by our Mammalian expression system and the target gene encoding Ser22-Thr356 is expressed with a 6His tag at the N-terminus.
    Purity
    > 95 % as determined by SDS-PAGE
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product THPO Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Thrombopoietin (THPO)
    Alternative Name
    Thrombopoietin/TPO (THPO Products)
    Background

    Background: Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets.Mature mouse Tpo shares 71 % and 81 % aa sequence homology with human and rat Tpo, respectively. It is an 80-85 kDa protein that consists of an N-terminal domain with homology to Erythropoietin (Epo) and a C-terminal domain that contains multiple N-linked and O-linked glycosylation sites. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

    Synonym: Thrombopoietin,C-mpl ligand,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor,Myeloproliferative leukemia virus oncogene ligand,THPO

    Molecular Weight
    36.4 kDa
    UniProt
    P40226
    Pathways
    JAK-STAT Signaling, Hormone Activity
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