Thrombomodulin Protein (THBD) (His tag)
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- Target See all Thrombomodulin (THBD) Proteins
- Thrombomodulin (THBD)
- Protein Type
- Recombinant
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Origin
- Rat
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Thrombomodulin protein is labelled with His tag.
- Purpose
- Recombinant Rat Thrombomodulin Protein (His Tag)
- Sequence
- Met1-Ser517
- Characteristics
- A DNA sequence encoding the rat THBD (O35370) (Met1-Ser517) was expressed with a polyhistidine tag at the C-terminus.
- Purity
- > 90 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method
- Top Product
- Discover our top product THBD Protein
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Thrombomodulin (THBD) protein (His tag)
THBD Origin: Mouse Host: Human Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Thrombomodulin (THBD)
- Alternative Name
- Thrombomodulin (THBD Products)
- Synonyms
- AHUS6 Protein, BDCA3 Protein, CD141 Protein, THPH12 Protein, THRM Protein, TM Protein, AI385582 Protein, THBD Protein, HAST Protein, HAST3 Protein, M-PST Protein, ST1A3/ST1A4 Protein, ST1A5 Protein, STM Protein, TL-PST Protein, thrombomodulin Protein, sulfotransferase family 1A member 3 Protein, THBD Protein, Thbd Protein, SULT1A3 Protein
- Background
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Background: Thrombomodulin, also known as THBD(CD141), is an integral membrane protein which reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.
Synonym: THBD
- Molecular Weight
- 55.2 kDa
- UniProt
- O35370
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