TXNDC17 Protein

Catalog No. ABIN7198224

Product Details

Target: TXNDC17 (Thioredoxin Domain Containing 17 (TXNDC17))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human TXNDC17/TRP14/TXNL5 Protein

Sequence: Met 1-Asp 123

Characteristics: A DNA sequence encoding the mature form of human TXNDC17 (Q9BRA2) (Met 1-Asp 123) was expressed and purified, with an initial Met.

Purity: > 97 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: TXNDC17 (Thioredoxin Domain Containing 17 (TXNDC17))

Alternative Name: TXNDC17//TXNL5 (TXNDC17 Products)

Synonyms: TRP14 Protein, TXNL5 Protein, 4831443O22Rik Protein, D11Ertd672e Protein, Txnl5 Protein, txnl5 Protein, zgc:91920 Protein, thioredoxin domain containing 17 Protein, TXNDC17 Protein, Txndc17 Protein, txndc17 Protein

Background:

Background: Cell surface A33 antigen, also known as glycoprotein A33, is a single-pass type I  membrane protein which is expressed in normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. Intracellular traffic and recycling to the cell surface appear to play a major role in GPA33 function and to have an influence on its surface density superseding translational regulation. GPA33 has become a promising target of immunologic therapy strategies, but its biologic function and potential role in tumorigenesis are unknown. EpCAM protein and GPA33 mRNA expressions are specific and sensitive markers of Barrett's metaplasia (BM). GPA33 may also play a role in cell-cell recognition and signaling.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: TRP14;TXNL5

Molecular Weight: 13.9 kDa

UniProt: Q9BRA2