Tspan-8 Protein (His tag)

Catalog No. ABIN7198214

Product Details

Target: Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Tspan-8 protein is labelled with His tag.

Purpose: Recombinant Human TSPAN8/Tetraspanin 8 Protein (His Tag)

Sequence: Lys110-Asn205

Characteristics: A DNA sequence encoding the human TSPAN8 (P19075) (Lys110-Asn205) was expressed with an N-terminal polyhistidine tag.

Purity: (87.8+10.7) % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))

Alternative Name: TSPAN8/Tetraspanin 8 (TSPAN8 Products)

Synonyms: tm4sf3 Protein, MGC64550 Protein, GB13255 Protein, TM4SF3 Protein, tetraspanin-8 Protein, tspan8 Protein, TSPAN8 Protein, CO-029 Protein, C76990 Protein, E330007O21Rik Protein, Tm4sf3 Protein, CO-29 Protein, TSPAN-8 Protein, tetraspanin 8 L homeolog Protein, tetraspanin-1 Protein, tetraspanin 8 Protein, tspan8.L Protein, LOC409511 Protein, TSPAN8 Protein, tspan8 Protein, Tspan8 Protein

Background:

Background: Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a negative regulator of Tspan8 expression. p53 as a regulator of melanoma invasion and the concept that reactivating p53 could provide a strategy for modulating not only proliferative but also invasive capacity in melanoma treatment. Tetraspanin 8 (TSPAN8) is a tumor-associated antigen implicated in tumor progression and metastasis. TSPAN8 may play an important role in mCRC cell invasion. TSPAN8 was overexpressed in human gastric cancer tissues and gastric cancer cell lines compared with the normal. TSPAN8 overexpression promoted cell proliferation and invasion, while TSPAN8 suppression inhibited cell proliferation and invasion. TSPAN8 could activate the ERK MAPK pathway in gastric cancer cells, and MEK-ERK inhibition reversed the effects of TSPAN8 overexpression on cell proliferation and invasion.

Synonym: CO-029,TM4SF3

Molecular Weight: 13.4 kDa

UniProt: P19075