Stathmin 1 Protein (STMN1) (His tag)

Catalog No. ABIN7319053

Product Details

Target: Stathmin 1 (STMN1)

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Stathmin 1 protein is labelled with His tag.

Purpose: Recombinant Human STMN1 Protein (His Tag)

Sequence: Ala2-Asp149

Characteristics: Recombinant Human Stathmin is produced by our E.coli expression system and the target gene encoding Ala2-Asp149 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Stathmin 1 (STMN1)

Alternative Name: STMN1 (STMN1 Products)

Synonyms: C1orf215 Protein, LAP18 Protein, Lag Protein, OP18 Protein, PP17 Protein, PP19 Protein, PR22 Protein, SMN Protein, 19k Protein, Lap18 Protein, Op18 Protein, P18 Protein, P19 Protein, Pig Protein, Pp17 Protein, Pp18 Protein, Pp19 Protein, Pr22 Protein, Smn Protein, prosolin Protein, op18 Protein, stathmin Protein, stmn1 Protein, stmn1a Protein, lag Protein, lap18 Protein, pp17 Protein, pp19 Protein, pr22 Protein, smn Protein, fj43c10 Protein, wu:fj38b07 Protein, wu:fj43c10 Protein, zgc:110159 Protein, cb959 Protein, wu:fb14e04 Protein, zgc:136942 Protein, stmn1-a Protein, stmn1b Protein, xo35 Protein, stathmin 1 Protein, stathmin 1 S homeolog Protein, stathmin 1b Protein, stathmin 1a Protein, stathmin-like Protein, stathmin Protein, stathmin 1 L homeolog Protein, STMN1 Protein, Stmn1 Protein, stmn1.S Protein, stmn1 Protein, stmn1b Protein, stmn1a Protein, LOC100229194 Protein, stmn1.L Protein

Background:

Background: Stathmin (STMN1) is a ubiquitous cytosolic phosphoprotein which belongs to the Stathmin family. STMN1 is expressed in many tissues, with the highest expression in the brain, spinal cord, and cerebellum. It can also be expressed in the colon, ovary, placenta, uterus, and trachea. STMN1 participates in the regulation of the microtubule filament structure by destabilizing microtubules. STMN1 promotes the disassembly of microtubules and prevents assembly. STMN1 is involved in the control of the learned and innate fear. STMN1 is an intracellular relay integrating regulatory signals of the cellular environment and as an Oncoprotein in regulation of the cell cycle. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Mutation in STMN1 effects cell homeostasis that may lead to tumorigenicity.

Synonym: Stathmin, Leukemia-Associated Phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17, STMN1, C1orf215, LAP18, OP18

Molecular Weight: 18.4 kDa

UniProt: P16949

Pathways: MAPK Signaling, Microtubule Dynamics