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SMAD5 Protein

SMAD5 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
Catalog No. ABIN7320167
  • Target See all SMAD5 Proteins
    SMAD5 (SMAD, Mothers Against DPP Homolog 5 (SMAD5))
    Protein Type
    Recombinant
    Origin
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Source
    • 4
    • 3
    • 2
    • 1
    Baculovirus infected Insect Cells
    Purpose
    Recombinant Mouse Smad5 Protein
    Sequence
    Thr2-Ser465
    Characteristics
    A DNA sequence encoding the mouse SMAD5 (P97454) (Thr2-Ser465) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
    Purity
    > 90 % as determined by SDS-PAGE
    Endotoxin Level
    < 1.0 EU per μg of the protein as determined by the LAL method.
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    Discover our top product SMAD5 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 500 mM Nacl,10 % glycerol, pH 8.0
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    SMAD5 (SMAD, Mothers Against DPP Homolog 5 (SMAD5))
    Alternative Name
    Smad5 (SMAD5 Products)
    Synonyms
    DWFC Protein, JV5-1 Protein, MADH5 Protein, Madh5 Protein, SBN Protein, fb67b04 Protein, mad Protein, madh5 Protein, sb:cb400 Protein, smd5 Protein, wu:fb67b04 Protein, SMAD5 Protein, DKFZp468M0619 Protein, 1110051M15Rik Protein, AI451355 Protein, Dwf-C Protein, MusMLP Protein, SMAD family member 5 Protein, SMAD5 Protein, Smad5 Protein, smad5 Protein
    Background

    Background: SMAD5 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. It is also involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.

    Synonym: 1110051M15Rik,AI451355,Dwf-C,Madh5,MusMLP

    Molecular Weight
    52.2 kDa
    UniProt
    P97454
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