SMAD5 Protein

Catalog No. ABIN7320167

Product Details

Target: SMAD5 (SMAD, Mothers Against DPP Homolog 5 (SMAD5))

Protein Type: Recombinant

Origin: Mouse

Source: Baculovirus infected Insect Cells

Purpose: Recombinant Mouse Smad5 Protein

Sequence: Thr2-Ser465

Characteristics: A DNA sequence encoding the mouse SMAD5 (P97454) (Thr2-Ser465) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.

Purity: > 90 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM Nacl,10 % glycerol, pH 8.0

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SMAD5 (SMAD, Mothers Against DPP Homolog 5 (SMAD5))

Alternative Name: Smad5 (SMAD5 Products)

Synonyms: DWFC Protein, JV5-1 Protein, MADH5 Protein, Madh5 Protein, SBN Protein, fb67b04 Protein, mad Protein, madh5 Protein, sb:cb400 Protein, smd5 Protein, wu:fb67b04 Protein, SMAD5 Protein, DKFZp468M0619 Protein, 1110051M15Rik Protein, AI451355 Protein, Dwf-C Protein, MusMLP Protein, SMAD family member 5 Protein, SMAD5 Protein, Smad5 Protein, smad5 Protein

Background:

Background: SMAD5 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. It is also involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.

Synonym: 1110051M15Rik,AI451355,Dwf-C,Madh5,MusMLP

Molecular Weight: 52.2 kDa

UniProt: P97454