SARS-CoV-2 NSP3 Protein
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- Target See all SARS-CoV-2 NSP3 (NSP3) Proteins
- SARS-CoV-2 NSP3 (NSP3) (SARS-CoV-2 Papain-Like Protease (NSP3))
- Protein Type
- Recombinant
- Origin
- SARS Coronavirus-2 (SARS-CoV-2)
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Source
- Escherichia coli (E. coli)
- Purpose
- Recombinant SARS-CoV-2 NSP3 protein
- Sequence
- Glu1024-Gln1198
- Characteristics
- Recombinant SARS-CoV-2 NSP3 is produced by E.coli expression system and the target gene encoding Glu1024-Gln1198 is expressed with N-His Tag
- Purity
- >90 % as determined by SDS-PAGE
- Biological Activity Comment
- Test in progress
- Top Product
- Discover our top product NSP3 Protein
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SARS-CoV-2 Papain-Like Protease (NSP3) (AA 1564-1878) protein (His tag)
NSP3 Origin: SARS Coronavirus-2 (SARS-CoV-2) Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS-PAGE. SDS
SARS-CoV-2 Papain-Like Protease (NSP3) protein (His tag)NSP3 Origin: SARS Coronavirus-2 (SARS-CoV-2) Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE. SDS
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- SARS-CoV-2 NSP3 (NSP3) (SARS-CoV-2 Papain-Like Protease (NSP3))
- Alternative Name
- SARS-CoV-2 NSP3 (NSP3 Products)
- Synonyms
- pp1ab Protein, ORF1a polyprotein;ORF1ab polyprotein Protein, ORF1ab Protein
- Target Type
- Viral Protein
- Background
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Background: The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
Synonym: nsp3,PL-PRO,Papain-like proteinase,X domain(Macro domain)
- Molecular Weight
- 22.03kDa
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