RPS6KB1 Protein (GST tag)
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- Target See all RPS6KB1 Proteins
- RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This RPS6KB1 protein is labelled with GST tag.
- Purpose
- Recombinant Human PS6K/RPS6KB1 Protein (GST Tag)
- Sequence
- Met 1-Leu525
- Characteristics
- A DNA sequence encoding the human RPS6KB1 (P23443-Alpha I) (Met1-Leu525) was fused with the GST tag at the N-terminus.
- Purity
- > 90 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product RPS6KB1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol, 1 mM GSH
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))
- Alternative Name
- PS6K/RPS6KB1 (RPS6KB1 Products)
- Synonyms
- PS6K Protein, S6K Protein, S6K-beta-1 Protein, S6K1 Protein, STK14A Protein, p70 S6KA Protein, p70(S6K)-alpha Protein, p70-S6K Protein, p70-alpha Protein, 10539 Protein, 7084 Protein, CG10539 Protein, DS6K Protein, Dmel\\CG10539 Protein, Dp70S6k Protein, Dp70[s6k] Protein, Dp70s6k Protein, S6k Protein, dS6K Protein, dS6k Protein, dp70[S6k] Protein, dp70s6k Protein, dps6k Protein, ds6k Protein, fs(3)07084 Protein, l(3)07084 Protein, p70 S6K Protein, p70/S6K Protein, p70S6K Protein, p70[S6 kinase] Protein, p70[S6K] Protein, p70[S6k] Protein, p70[S6kinase] Protein, p70s6K Protein, s6k Protein, s6k11 Protein, 2610318I15Rik Protein, 4732464A07Rik Protein, 70kDa Protein, AA959758 Protein, AI256796 Protein, AI314060 Protein, p70/85s6k Protein, p70s6k Protein, p70s6k-A Protein, p70-s6k Protein, ps6k Protein, rps6kb1 Protein, rps6kb1-A Protein, s6K1 Protein, stk14a Protein, fc51h01 Protein, wu:fc51h01 Protein, zgc:55713 Protein, ribosomal protein S6 kinase B1 Protein, Ribosomal protein S6 kinase Protein, ribosomal protein S6 kinase, polypeptide 1 Protein, ribosomal protein S6 kinase B1 L homeolog Protein, ribosomal protein S6 kinase B1 S homeolog Protein, ribosomal protein S6 kinase b, polypeptide 1b Protein, RPS6KB1 Protein, S6k Protein, Rps6kb1 Protein, rps6kb1.L Protein, rps6kb1.S Protein, rps6kb1b Protein
- Background
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Background: PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is dissociated from the EIF3 complex and activated upon mitogenic stimulation, phosphorylation by the mammalian target of mTOR complex 1 (mTORC1). Its active form then phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. PS6K also functions in cell proliferation, cell growth and cell cycle progression.
Synonym: p70 S6KA,p70(S6K)-alpha,p70-alpha,p70-S6K,PS6K,RPS6KB1,S6K,S6K-beta-1,S6K1,STK14A
- Molecular Weight
- 85.4 kDa
- Pathways
- PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Cell Size, Skeletal Muscle Fiber Development, Feeding Behaviour, G-protein mediated Events, Smooth Muscle Cell Migration, Interaction of EGFR with phospholipase C-gamma, Warburg Effect
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