Resistin Protein (RETN) (His tag)

Catalog No. ABIN7319264

Product Details

Target: Resistin (RETN)

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Resistin protein is labelled with His tag.

Purpose: Recombinant Human Resistin Protein (His Tag)

Sequence: Lys19-Pro108

Characteristics: Recombinant Human Adipose tissue-specific secretory factor is produced by our E.coli expression system and the target gene encoding Lys19-Pro108 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Acetic acid, pH 3.0.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Resistin (RETN)

Alternative Name: Resistin (RETN Products)

Synonyms: RETN Protein, ADSF Protein, FIZZ3 Protein, RETN1 Protein, RSTN Protein, XCP1 Protein, Fizz3 Protein, Rstn Protein, Xcp4 Protein, resistin Protein, RETN Protein, Retn Protein

Background:

Background: Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa, the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus (T2DM). Resistin has been shown to cause "high levels of 'bad' cholesterol (low-density lipoprotein or LDL), increasing the risk of heart disease, resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver. Potentially links obesity to diabetes.

Synonym: Resistin, Adipose tissue-specific secretory factor, Cysteine-rich secreted protein FIZZ3, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, FIZZ3, HXCP1, RSTN, RETN,ADSF,FIZZ3,RETN1,XCP1

Molecular Weight: 10.6 kDa

NCBI Accession: NP_065148

Pathways: Feeding Behaviour, Smooth Muscle Cell Migration