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Prosaposin Protein (PSAP) (His tag)

PSAP Origin: Human Host: HEK-293 Cells Recombinant > (79.8+19.7) % as determined by reducing SDS-PAGE..
Catalog No. ABIN7317152
  • Target See all Prosaposin (PSAP) Proteins
    Prosaposin (PSAP)
    Protein Type
    Recombinant
    Origin
    • 4
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 3
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Prosaposin protein is labelled with His tag.
    Purpose
    Recombinant Human PSAP/Prosaposin Protein (His Tag)
    Sequence
    Met 1-Asn524
    Characteristics
    A DNA sequence encoding the human PSAP (NP_002769.1) (Met1-Asn524) was expressed with a polyhistidine tag at the C-terminus.
    Purity
    > (79.8+19.7) % as determined by reducing SDS-PAGE..
    Endotoxin Level
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Top Product
    Discover our top product PSAP Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Prosaposin (PSAP)
    Alternative Name
    PSAP/Prosaposin (PSAP Products)
    Synonyms
    GLBA Protein, SAP1 Protein, AI037048 Protein, SGP-1 Protein, SGP1A Protein, cb759 Protein, wu:fa14a06 Protein, wu:fb36e02 Protein, wu:fb58g07 Protein, PSAP Protein, PSP-A Protein, SFTPA1B Protein, SP-A Protein, prosaposin Protein, surfactant protein A1 Protein, PSAP Protein, Psap Protein, psap Protein, LOC100011417 Protein, LOC100304726 Protein, LOC100526719 Protein, SFTPA1 Protein
    Background

    Background: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

    Synonym: GLBA,SAP1

    Molecular Weight
    57.9 kDa
    NCBI Accession
    NP_002769
    Pathways
    Positive Regulation of Endopeptidase Activity
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