Podoplanin Protein (PDPN) (His tag)

Catalog No. ABIN7320345

Product Details

Target: Podoplanin (PDPN)

Protein Type: Recombinant

Origin: Mouse

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This Podoplanin protein is labelled with His tag.

Purpose: Recombinant Mouse Podoplanin/PDPN Protein (His Tag)

Sequence: Met 1-Lys 133

Characteristics: A DNA sequence encoding the mouse PDPN N-terminal fragment (NP_034459.2) (Met 1-Lys 133) was expressed,with a C-terminal polyhistidine tag.

Purity: > 92 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Podoplanin (PDPN)

Alternative Name: Podoplanin/PDPN (PDPN Products)

Synonyms: PDPN Protein, AGGRUS Protein, GP36 Protein, GP40 Protein, Gp38 Protein, HT1A-1 Protein, OTS8 Protein, PA2.26 Protein, T1A Protein, T1A-2 Protein, OTS-8 Protein, RANDAM-2 Protein, T1-alpha Protein, T1a Protein, T1alpha Protein, E11 Protein, RTI40 Protein, podoplanin Protein, PDPN Protein, Pdpn Protein

Background:

Background: Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: Gp38;OTS-8;RANDAM-2;T1-alpha;T1a;T1alpha;Podoplanin; Aggrus; Glycoprotein 38; PA2.26 antigen

Molecular Weight: 13 kDa

NCBI Accession: NP_034459

Pathways: Dicarboxylic Acid Transport