Oncostatin M Receptor Protein (OSMR) (AA 28-739) (His tag)
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- Target See all Oncostatin M Receptor (OSMR) Proteins
- Oncostatin M Receptor (OSMR)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 28-739
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This Oncostatin M Receptor protein is labelled with His tag.
- Purpose
- Recombinant Human OSMR/IL31RB Protein (aa 28-739, His Tag)
- Sequence
- Glu28-Ser739
- Characteristics
- Recombinant Human Oncostatin-M-Specific Receptor Subunit beta is produced by our Mammalian expression system and the target gene encoding Glu28-Ser739 is expressed with a 6His tag at the C-terminus.
- Purity
- > 90 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product OSMR Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Oncostatin M Receptor (OSMR)
- Alternative Name
- OSMR/IL31RB (OSMR Products)
- Synonyms
- OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein
- Background
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Background: Oncostatin-M-Specific Receptor Subunit β (OSMRβ) is a 150 - 180 kDa member of the IL-6 receptor family. OSMRβ associates with gp130 to form the type II OSM receptor, the receptor is responsive to OSM. Gp130 subunit is shared by other IL-6 family cytokine receptors, and OSMRβ associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31. The human OSMRβ cDNA encodes a 979 amino acid (aa) precursor, the precursor includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aatransmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three Fibronectin type-III domains.
Synonym: Oncostatin-M-Specific Receptor Subunit Beta, Interleukin-31 Receptor Subunit Beta, IL-31 Receptor Subunit Beta, IL-31R Subunit Beta, IL-31R-Beta, IL-31RB, OSMR,OSMRB,PLCA1
- Molecular Weight
- 82.0 kDa
- UniProt
- Q99650
- Pathways
- JAK-STAT Signaling, Growth Factor Binding
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