OMG Protein (AA 1-420) (His tag)
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- Target See all OMG Proteins
- OMG (Oligodendrocyte Myelin Glycoprotein (OMG))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 1-420
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This OMG protein is labelled with His tag.
- Purpose
- Recombinant Human OMGP/OMG Protein (aa 1-420, His Tag)(Active)
- Sequence
- Met 1-Asn 420
- Characteristics
- A DNA sequence encoding the mature form of human OMGP (P23515-1) (Met 1-Asn 420) without the pro peptide was expressed, fused with a polyhistidine tag at the C-terminus.
- Purity
- > 97 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. Immobilized OMG (0.8 μg/ml, 100 μl/well) will mediate >20% C6 cell adhesion.
- Top Product
- Discover our top product OMG Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- OMG (Oligodendrocyte Myelin Glycoprotein (OMG))
- Alternative Name
- OMGP/OMG (OMG Products)
- Synonyms
- OMGP Protein, omgp Protein, MGC107958 Protein, OMG Protein, DKFZp459F1351 Protein, oligodendrocyte myelin glycoprotein Protein, myelin oligodendrocyte glycoprotein Protein, oligodendrocyte-myelin glycoprotein Protein, OMG Protein, MOG Protein, Omg Protein, omg Protein
- Background
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Background: Oligodendrocyte-myelin glycoprotein; also known as OMG and OMGP; is a cell membrane protein which contains eight LRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participats in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR; the receptor for Nogo. This function requires its leucine-rich repeat domain; a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation; neuronal sprouting and myelination are crucial processes involved in brain development and regeneration after injury.
Synonym: OMGP
- Molecular Weight
- 46 kDa
- Pathways
- Neurotrophin Signaling Pathway, Regulation of Cell Size
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