NOL3 Protein
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- Target See all NOL3 Proteins
- NOL3 (Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purpose
- Recombinant Human NOL3 Protein
- Sequence
- Met 1-Ser208
- Characteristics
- Recombinant Human Nucleolar Protein 3 is produced by our E.coli expression system and the target gene encoding Met1-Ser208 is expressed.
- Purity
- > 90 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product NOL3 Protein
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Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (His tag)
NOL3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (GST tag)NOL3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (Transcript Variant 3) protein (His tag)NOL3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (His-SUMO Tag)NOL3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) protein (Myc-DYKDDDDK Tag)NOL3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 25 mM TrisHCl, 1 mM DTT, 1 mM EDTA, 2 mM β-ME, 20 % Glycerol, pH 7.5.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- NOL3 (Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3))
- Alternative Name
- NOL3 (NOL3 Products)
- Synonyms
- ARC Protein, FCM Protein, MYP Protein, NOP Protein, NOP30 Protein, B430311C09Rik Protein, MYC Protein, Nop30 Protein, Arc Protein, nucleolar protein 3 Protein, nucleolar protein 3 (apoptosis repressor with CARD domain) Protein, NOL3 Protein, Nol3 Protein
- Background
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Background: Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation. It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.
Synonym: Nucleolar Protein 3, Apoptosis Repressor With CARD, Muscle-Enriched Cytoplasmic Protein, Myp, Nucleolar Protein of 30 kDa, Nop30
- Molecular Weight
- 22.6 kDa
- UniProt
- O60936
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