NINJ1 Protein (Fc Tag)

Catalog No. ABIN7321087

Product Details

Target: NINJ1 (Ninjurin 1 (NINJ1))

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purification tag / Conjugate: This NINJ1 protein is labelled with Fc Tag.

Purpose: Recombinant Rat Ninjurin-1/NINJ1 Protein (Fc Tag)

Sequence: Met 1-Pro 79

Characteristics: A DNA sequence encoding the rat NINJ1 (P70617) extracellular domain (Met 1-Pro 79) was fused with the Fc region of human IgG1 at the N-terminus.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: NINJ1 (Ninjurin 1 (NINJ1))

Alternative Name: Ninjurin-1/NINJ1 (NINJ1 Products)

Synonyms: nin1 Protein, MGC79511 Protein, ninjurin Protein, NIN1 Protein, NINJURIN Protein, AU024536 Protein, ninjurin 1 Protein, ninjurin 1 L homeolog Protein, NINJ1 Protein, ninj1 Protein, ninj1.L Protein, Ninj1 Protein

Background:

Background: Ninjurin-1, also known as NINJ1, is a member of the Ninjurin family of transmembrane (TM) proteins. It is expressed in CD19(+) CD10(+) B-cell progenitor cells and higher levels in B-lineage acute lymphoblastic leukemia cells. Ninjurin-1 is expressed also in a number of other adult and embryonic tissues, predominantly in epithelial cells. Its expression is upregulated after axotomy in neurons and in Schwann cells surrounding the distal nerve segment. Upregulated expression of ninjurin-1 has been identified as a marker of minimal residual disease in B-lineage acute lymphoblastic leukemia. It mediates homophilic adhesion, and promotes neurite extension of dorsal root ganglion neurons in vitro. Ninjurin-1 has been found to show a high expression level in the liver tissue of patients with hepatocellular carcinoma, and this seems to be associated with cases of cirrhosis and chronic viral hepatitis. It has been reported that NINJURIN increases p21 expression and induces cellular senescence in human hepatoma cells.

Synonym: NINJ1

Molecular Weight: 37 kDa

UniProt: P70617