Neuroligin 3 Protein (NLGN3) (His tag)

Catalog No. ABIN7317636

Product Details

Target: Neuroligin 3 (NLGN3)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Neuroligin 3 protein is labelled with His tag.

Purpose: Recombinant Human Neuroligin-3/NLGN3 Protein (His Tag)

Sequence: Met 1-Ser 689

Characteristics: A DNA sequence encoding the human NLGN3 isoform 2 (Q9NZ94-2) extracellular domain (Met 1-Ser 689) was expressed, fused with a polyhistidine tag at the C-terminus.

Purity: > 92 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Neuroligin 3 (NLGN3)

Alternative Name: Neuroligin-3/NLGN3 (NLGN3 Products)

Synonyms: Nlgn3 Protein, GB18290 Protein, hnl3 Protein, NLGN3 Protein, CCE-L1 Protein, NV16744 Protein, Nv1604741 Protein, HNL3 Protein, A230085M13Rik Protein, NL3 Protein, neuroligin 3 Protein, neuroligin 3 S homeolog Protein, NLG-3 Protein, nlgn3.S Protein, NLGN3 Protein, LOC659852 Protein, LOC100121155 Protein, nlgn3 Protein, Nlgn3 Protein

Background:

Background: Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface proteins that interact with neurexins (beta-Nxs), another class of neuronal cell-surface proteins, one of each class functioning together in synapse formation. Neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. NLGN1 and NLGN2 isoforms are concentrated at glutamatergic and GABAergic synapses, respectively, but the cellular expression and synaptic localization of the endogenous. NLGN3 was enriched in brain, where NLGN3 protein levels increased during postnatal development, coinciding with the peak of synaptogenesis. The NLGN3 is a synaptic adhesion molecule that is a shared component of glutamatergic and GABAergic synapses. Mutations in NLGN3 gene may be associated with autism and Asperger syndrome.

Synonym: HNL3

Molecular Weight: 74 kDa

Pathways: Synaptic Membrane