NFASC Protein (Fc Tag)
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- Target See all NFASC Proteins
- NFASC (Neurofascin (NFASC))
- Protein Type
- Recombinant
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NFASC protein is labelled with Fc Tag.
- Purpose
- Recombinant Human NFASC/Neurofascin protein (Fc Tag)
- Sequence
- Met 1-Gln939
- Characteristics
- A DNA sequence encoding the human NFASC (XP_011507630.1) (Met1-Gln939) was expressed with the Fc region of human IgG1 at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Neurofascin (NFASC) (AA 661-758) protein (GST tag)
NFASC Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Neurofascin (NFASC) (AA 1239-1347) protein (His tag)NFASC Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Neurofascin (NFASC) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)NFASC Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Neurofascin (NFASC) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)NFASC Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- NFASC (Neurofascin (NFASC))
- Alternative Name
- NFASC/Neurofascin (NFASC Products)
- Synonyms
- sc:d0205 Protein, NF Protein, NRCAML Protein, AA387016 Protein, D430023G06Rik Protein, mKIAA0756 Protein, neurofascin Protein, neurofascin homolog (chicken) a Protein, NFASC Protein, nfasca Protein, Nfasc Protein
- Background
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Background: NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.
Synonym: NF,NRCAML
- Molecular Weight
- 130 kDa
- NCBI Accession
- NP_001005388
- Pathways
- Cell-Cell Junction Organization
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