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NFASC Protein (Fc Tag)

NFASC Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7197149
  • Target See all NFASC Proteins
    NFASC (Neurofascin (NFASC))
    Protein Type
    Recombinant
    Origin
    Human
    Source
    • 3
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This NFASC protein is labelled with Fc Tag.
    Purpose
    Recombinant Human NFASC/Neurofascin protein (Fc Tag)
    Sequence
    Met 1-Gln939
    Characteristics
    A DNA sequence encoding the human NFASC (XP_011507630.1) (Met1-Gln939) was expressed with the Fc region of human IgG1 at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    NFASC (Neurofascin (NFASC))
    Alternative Name
    NFASC/Neurofascin (NFASC Products)
    Synonyms
    sc:d0205 Protein, NF Protein, NRCAML Protein, AA387016 Protein, D430023G06Rik Protein, mKIAA0756 Protein, neurofascin Protein, neurofascin homolog (chicken) a Protein, NFASC Protein, nfasca Protein, Nfasc Protein
    Background

    Background: NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.

    Synonym: NF,NRCAML

    Molecular Weight
    130 kDa
    NCBI Accession
    NP_001005388
    Pathways
    Cell-Cell Junction Organization
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