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MYOC Protein (His tag)

MYOC Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7197075
  • Target See all MYOC Proteins
    MYOC (Myocilin (MYOC))
    Protein Type
    Recombinant
    Origin
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 6
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This MYOC protein is labelled with His tag.
    Purpose
    Recombinant Human MYOC/Myocilin Protein (His Tag)
    Sequence
    Met 1-Met 504
    Characteristics
    A DNA sequence encoding the full length of human MYOC (Q99972) (Met 1-Met 504) was fused with a polyhistidine tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product MYOC Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    MYOC (Myocilin (MYOC))
    Alternative Name
    MYOC/Myocilin (MYOC Products)
    Synonyms
    MYOC Protein, MGC136645 Protein, zgc:136645 Protein, AI957332 Protein, GLC1A Protein, TIGR Protein, GPOA Protein, JOAG Protein, JOAG1 Protein, myocilin Protein, Tigr Protein, myocilin Protein, MYOC Protein, myoc Protein, Myoc Protein
    Background

    Background: Myocilin, also known as Trabecular meshwork-induced glucocorticoid response protein, MYOC and GLC1A, is a protein which contains one olfactomedin-like domain. Myocilin / MYOC may participate in the obstruction of fluid outflow in the trabecular meshwork. Myocilin / MYOC is expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart and other tissues. Myocilin / MYOC is expressed predominantly in the retina. In normal eyes, it is found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma. Defects in Myocilin / MYOC may contribute to primary congenital glaucoma type 3A (GLC3A). Defects in MYOC may also contribute to this phenotype via digenic inheritance. GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema.

    Synonym: GLC1A;GPOA;JOAG;JOAG1;myocilin;TIGR

    Molecular Weight
    54.7 kDa
    UniProt
    Q99972
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