MAPK12 Protein

Catalog No. ABIN7317045

Product Details

Target: MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Purpose: Recombinant Human ERK3/MAPK12 Protein

Sequence: Met 1-Leu 367

Characteristics: A DNA sequence encoding the human MAPK12 (P53778) (Met1-Leu367) was fused with two additional amino acids (Gly & Pro) at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))

Alternative Name: ERK3/MAPK12 (MAPK12 Products)

Synonyms: ATMPK12 Protein, MAPK12 Protein, T3F17.28 Protein, mitogen-activated protein kinase 12 Protein, MGC160082 Protein, si:dkey-14d8.5 Protein, erk6 Protein, etID309866.18 Protein, mapk12 Protein, sapk3 Protein, wu:fa05c12 Protein, zgc:101695 Protein, ERK3 Protein, ERK6 Protein, P38GAMMA Protein, PRKM12 Protein, SAPK-3 Protein, SAPK3 Protein, AW123708 Protein, Erk6 Protein, P38gamma Protein, Prkm12 Protein, Sapk3 Protein, mitogen-activated protein kinase 12 Protein, mitogen-activated protein kinase 12b Protein, mitogen-activated protein kinase 12a Protein, MPK12 Protein, MAPK12 Protein, mapk12b Protein, mapk12a Protein, Mapk12 Protein

Background:

Background: ERK3; also known as MAPK12 and p38-gamma; belongs to the protein kinase superfamily; CMGC Ser/Thr protein kinase family and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly; p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1; prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

Synonym: ERK-6;ERK3;ERK6;MAPK12;P38GAMMA;PRKM12;SAPK-3;SAPK3;P38-gamma

Molecular Weight: 42.1 kDa

UniProt: P53778

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C, BCR Signaling, S100 Proteins