METAP1 Protein
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- Target See all METAP1 Proteins
- METAP1 (Methionyl Aminopeptidase 1 (METAP1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purpose
- Recombinant Human METAP1 Protein
- Sequence
- Met1-Phe386
- Characteristics
- Recombinant Human METAP1 is produced by our E.coli expression system and the target gene encoding Met1-Phe386 is expressed.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product METAP1 Protein
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Methionyl Aminopeptidase 1 (METAP1) (AA 1-386) protein (His tag)
METAP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Methionyl Aminopeptidase 1 (METAP1) (AA 1-272) protein (GST tag)METAP1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Methionyl Aminopeptidase 1 (METAP1) protein (Myc-DYKDDDDK Tag)METAP1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris,500 mM NaCl,10 % glycerol, pH 8.0.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- METAP1 (Methionyl Aminopeptidase 1 (METAP1))
- Alternative Name
- METAP1 (METAP1 Products)
- Synonyms
- MGC64362 Protein, METAP1 Protein, metap1 Protein, DKFZp468B1413 Protein, LOC100228334 Protein, DDBDRAFT_0205763 Protein, DDBDRAFT_0235405 Protein, DDB_0205763 Protein, DDB_0235405 Protein, MAP1A Protein, MetAP1A Protein, 1700029C17Rik Protein, AW047992 Protein, mKIAA0094 Protein, Metap1 Protein, im:7047238 Protein, wu:fc84e12 Protein, zgc:110093 Protein, methionyl aminopeptidase 1 S homeolog Protein, methionyl aminopeptidase 1 Protein, methionine aminopeptidase 1 Protein, methionyl aminopeptidase 1 L homeolog Protein, metap1.S Protein, METAP1 Protein, metap1 Protein, Metap1 Protein, metap1.L Protein
- Background
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Background: Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.
Synonym: Methionine aminopeptidase 1, MAP 1, MetAP 1, Peptidase M 1, METAP1,MAP1A,MetAP1A
- Molecular Weight
- 43.2 kDa
- UniProt
- P53582
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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