LY86 Protein (His tag)
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- Target See all LY86 Proteins
- LY86 (Lymphocyte Antigen 86 (LY86))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This LY86 protein is labelled with His tag.
- Purpose
- Recombinant Mouse MD1 Protein (His Tag)
- Sequence
- Met 1-Ser 162
- Characteristics
- A DNA sequence encoding the extracellular domain (Met 1-Ser 162) of mouse LY86 (NP_034875.1) precursor was expressed with a C-terminal polyhistidine tag.
- Purity
- > 92 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product LY86 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- LY86 (Lymphocyte Antigen 86 (LY86))
- Alternative Name
- MD1 (LY86 Products)
- Synonyms
- MD-1 Protein, MMD-1 Protein, dJ80N2.1 Protein, MD1 Protein, LY86 Protein, lymphocyte antigen 86 Protein, LY86 Protein, Ly86 Protein
- Background
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Background: MD-1 and MD-2 are secretory glycoproteins that exist on the cell surface in complexes with transmembrane proteins. MD-1 is anchored by radioprotective 105 (RP105) which is a molecule containing leucine-rich repeats and is expressed on B cells, dentritic cells and macrophages, while MD-2 is associated with TLR4. MD-1 is required for efficient RP105 cell surface expression and function. It is indicated that the RP105/MD1 complex, in conjunction with TLR4, mediates the innate immune response to LPS in B cells, and also plays a role in protecting against apoptosis, B-cell proliferation, etc. Mouse MD-1 cDNA encodes a 162 amino acid precursor protein with a putative 19 aa signal peptide and two potential N-linked glycosylation sites. It shares 40 % and 66 % amino acid sequence identity with chicken and human MD-1 respectively. MD-1 is mainly expressed in spleen, and also detectable in liver, brain, thymus, and kidney.
Synonym: MD-1,MD1
- Molecular Weight
- 18 kDa
- NCBI Accession
- NP_034875
- Pathways
- Toll-Like Receptors Cascades
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