LAIR2 Protein
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- Target See all LAIR2 Proteins
- LAIR2 (Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Origin
- Human
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Source
- HEK-293 Cells
- Purpose
- Recombinant Human LAIR2/CD306 Protein (Active)
- Sequence
- Met 1-Pro 152
- Characteristics
- A DNA sequence encoding the human LAIR2 (NP_002279.2) (Met 1-Pro 152) was expressed and purified.
- Purity
- > 93 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by the ability of the immobilized protein to support the adhesion of HT-29 human colon adenocarcinoma cells. When 5 x 10E4 cells/well are added to recombiannt human LAIR2 coated plates (50 μg/ml with 100 μl/well), >30% will adhere after 30 minutes at 37°C. Optimal concentration depends on cell type as well as the application or research objectives.
- Top Product
- Discover our top product LAIR2 Protein
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Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) (AA 22-152) protein (His-Avi Tag)
LAIR2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) (AA 22-152) protein (His-Avi Tag,Biotin)LAIR2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) protein (Fc Tag)LAIR2 Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) (AA 1-152) protein (GST tag)LAIR2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) (AA 22-152) protein (His tag,AVI tag,Biotin)LAIR2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 50 mM Tris, 0.7M NaCl, pH 8.0
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- LAIR2 (Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2))
- Alternative Name
- LAIR2/CD306 (LAIR2 Products)
- Synonyms
- CD306 Protein, leukocyte associated immunoglobulin like receptor 2 Protein, LAIR2 Protein
- Background
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Background: Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD306, is a 131 amino acid protein containing one lg-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.
Synonym: Leukocyte-Associated Immunoglobulin-Like Receptor 2, LAIR-2, CD306, LAIR2
- Molecular Weight
- 14.1 kDa
- NCBI Accession
- NP_002279
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