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Kallikrein 7 Protein (KLK7) (His tag)

KLK7 Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7319371
  • Target See all Kallikrein 7 (KLK7) Proteins
    Kallikrein 7 (KLK7)
    Protein Type
    Recombinant
    Origin
    • 12
    • 5
    • 3
    Human
    Source
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    Human Cells
    Purification tag / Conjugate
    This Kallikrein 7 protein is labelled with His tag.
    Purpose
    Recombinant Human Kallikrein 7/KLK7 Protein (His Tag)
    Sequence
    Glu23-His252
    Characteristics
    Recombinant Human Kallikrein 7 is produced by our Mammalian expression system and the target gene encoding Glu23-His252 is expressed with a 6His tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product KLK7 Protein
  • Restrictions
    For Research Use only
  • Format
    Frozen, Liquid
    Buffer
    Supplied as a 0.2 μm filtered solution of 20 mM HEPES, 150 mM NaCl, pH 7.5.
    Storage
    -20 °C
    Storage Comment
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target
    Kallikrein 7 (KLK7)
    Alternative Name
    Kallikrein 7/KLK7 (KLK7 Products)
    Synonyms
    Prss6 Protein, SCCE Protein, PRSS6 Protein, hK7 Protein, kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Protein, kallikrein-related peptidase 7 Protein, kallikrein related peptidase 7 Protein, Klk7 Protein, KLK7 Protein
    Background

    Background: Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.

    Synonym: Kallikrein-7, hK7, Serine Protease 6, Stratum Corneum Chymotryptic Enzyme, hSCCE, KLK7, PRSS6, SCCE

    Molecular Weight
    26.2 kDa
    UniProt
    P49862
    Pathways
    Complement System
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