JAG1 Protein (Fc Tag)
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- Target See all JAG1 Proteins
- JAG1 (Jagged 1 (JAG1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This JAG1 protein is labelled with Fc Tag.
- Purpose
- Recombinant Human Jagged 1/JAG1 Protein (Fc Tag)
- Sequence
- Gln34-Ser1046
- Characteristics
- Recombinant Human jagged-1 is produced by our Mammalian expression system and the target gene encoding Gln34-Ser1046 is expressed with a Fc tag at the C-terminus.
- Purity
- > 90 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product JAG1 Protein
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Jagged 1 (JAG1) (AA 531-620) protein (GST tag)
JAG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Jagged 1 (JAG1) (AA 37-119) protein (GST tag)JAG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Jagged 1 (JAG1) (AA 1-1067), (Extracellular Domain) (Active) protein (Fc Tag)JAG1 Origin: Human Host: HEK-293 Cells Recombinant >90 % (SDS-PAGE) SDS Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- JAG1 (Jagged 1 (JAG1))
- Alternative Name
- Jagged 1/JAG1 (JAG1 Products)
- Background
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Background: Protein jagged-1 I, also known as Jagged-1, JAGL1, HJ1, JAG1 and CD339, is a single-pass type I membrane protein. JAG1 contains one DSL domain and sixteen EGF-like domain. JAG1 acts as a ligand for multiple Notch receptors and is involved in the mediation of Notch signaling. JAG1 may participate in early and late stages of mammalian cardiovascular development, JAG1 inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1 are the cause of Alagille syndrome type 1, which is autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations.
Synonym: Protein jagged-1 I, Jagged-1, JAGL1, HJ1, JAG1 and CD339,AGS,AHD,AWS,Jagged 1
- Molecular Weight
- 138.5 kDa
- NCBI Accession
- NP_000205
- Pathways
- Notch Signaling, Stem Cell Maintenance
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