IL1RN Protein
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- Target See all IL1RN Proteins
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purpose
- Recombinant Mouse IL-1RA/IL1RN Protein
- Sequence
- Arg27-Gln178
- Characteristics
- Recombinant Mouse Interleukin-1 Receptor Antagonist Protein is produced by our E.coli expression system and the target gene encoding Arg27-Gln178 is expressed.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product IL1RN Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- Alternative Name
- IL-1RA/IL1RN (IL1RN Products)
- Synonyms
- DIRA Protein, ICIL-1RA Protein, IL-1RN Protein, IL-1ra Protein, IL-1ra3 Protein, IL1F3 Protein, IL1RA Protein, IRAP Protein, MVCD4 Protein, IRAP1 Protein, IL1RN Protein, IL-1RA Protein, F630041P17Rik Protein, interleukin 1 receptor antagonist Protein, interleukin 1 receptor antagonist-like Protein, IL1RN Protein, Il1rn Protein, IL1RNL Protein
- Background
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Background: Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26 % and 19 % identity with its homologues IL-1 beta and IL-1 alpha, respectively. Il1rn can Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling, but has no interleukin-1 like activity. Recently, an recombinant human Il1rn protein is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.
Synonym: IL-1RN,IL-1ra,IRAP,IL1 inhibitor,Il1rn,Interleukin-1 Receptor Antagonist Protein
- Molecular Weight
- 17.5 kDa
- UniProt
- P25085
- Pathways
- NF-kappaB Signaling, Hormone Transport, Cancer Immune Checkpoints
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