IFNGR1 Protein (His tag)
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- Target See all IFNGR1 Proteins
- IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IFNGR1 protein is labelled with His tag.
- Purpose
- Recombinant Human IFNGR1 Protein (His Tag)(Active)
- Sequence
- Met 1-Gly 245
- Characteristics
- A DNA sequence encoding the extracellular domain (Met 1-Gly 245) of human IFN-γR1 pre-protein (NP_000407.1) was expressed, fused with a polyhistidine tag at the C-terminus.
- Purity
- > 97 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit rhIFN-γ mediated protection of WISH cells infected with vesicular stomatitis virus(VSV).The ED50 for this effect is typically 2-8 μg/mL.
- Top Product
- Discover our top product IFNGR1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))
- Alternative Name
- IFNGR1 (IFNGR1 Products)
- Synonyms
- CD119 Protein, IFNGR Protein, IFN-gammaR Protein, Ifgr Protein, Ifngr Protein, Nktar Protein, IFNGR1 Protein, MGC129098 Protein, ifngr1 Protein, MGC194858 Protein, MGC194873 Protein, zgc:194858 Protein, cd119 Protein, ifngr Protein, DKFZp469K1232 Protein, interferon gamma receptor 1 Protein, cytokine receptor family member B17 Protein, IFNGR1 Protein, Ifngr1 Protein, crfb17 Protein, ifngr1 Protein
- Background
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Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD119 (cluster of differentiation 119), also known as IFNGR1 ( interferon gamma receptor 1), is part of the heterodimeric gamma interferon receptor which consists of IFNGR1 (CD119) and IFNGR2. The IFNGR1 gene encodes the ligand-binding chain (alpha) of the interteron receptor while IFNGR gene encodes the non-ligand binding partner. The ability of the interferon-γ was achieved through binding to the interferon receptor CD119. After binding, the products of activated T-lymphocytes interferon-γ exerts antiviral activity, growth inhibitory effect, and several immune- regulatory activities on a variety of cell types.
Synonym: CD119;IFNGR;IMD27A;IMD27B;Interferon gamma receptor 1;IFNGR1
- Molecular Weight
- 27.3 kDa
- NCBI Accession
- NP_000407
- Pathways
- Interferon-gamma Pathway
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