IGFBP6 Protein (His tag)
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- Target See all IGFBP6 Proteins
- IGFBP6 (Insulin-Like Growth Factor Binding Protein 6 (IGFBP6))
- Protein Type
- Recombinant
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Origin
- Rat
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IGFBP6 protein is labelled with His tag.
- Purpose
- Recombinant Rat IGFBP6/IBP6 Protein (His Tag)
- Sequence
- Met1-Gly226
- Characteristics
- A DNA sequence encoding the rat Igfbp6 (NP_037236.1) (Met1-Gly226) was expressed with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg protein as determined by the LAL method.
- Top Product
- Discover our top product IGFBP6 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- IGFBP6 (Insulin-Like Growth Factor Binding Protein 6 (IGFBP6))
- Alternative Name
- IGFBP6/IBP6 (IGFBP6 Products)
- Synonyms
- IBP6 Protein, IGFBP-6 Protein, IGF-BP6 Protein, RBP6A Protein, IGFBP6 Protein, igfbp6 Protein, insulin like growth factor binding protein 6 Protein, insulin-like growth factor binding protein 6 Protein, IGFBP6 Protein, Igfbp6 Protein, IGFBP-6 Protein, igfbp6 Protein
- Background
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Background: Insulin-like growth factor binding protein 6 (IGFBP6) is a 24- kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. IGFBP6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.
Synonym: Igfbp-6
- Molecular Weight
- 22.9 kDa
- NCBI Accession
- NP_037236
- Pathways
- WNT Signaling, Myometrial Relaxation and Contraction
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