IGF2 Protein
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- Target See all IGF2 Proteins
- IGF2 (Insulin-Like Growth Factor 2 (IGF2))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purpose
- Recombinant Human IGF-II/IGF2 Protein (Active)
- Sequence
- Ala25-Glu91
- Characteristics
- Recombinant Human Long Insulin-Like Growth Factor II is produced by our E.coli expression system and the target gene encoding Ala25-Glu91 is expressed.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. The ED50 for this effect is 15.7 ng/ml.
- Top Product
- Discover our top product IGF2 Protein
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Insulin-Like Growth Factor 2 (IGF2) (AA 1-113) protein (GST tag)
IGF2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Insulin-Like Growth Factor 2 (IGF2) (AA 1-180) protein (GST tag)IGF2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Insulin-Like Growth Factor 2 (IGF2) (AA 25-91) (Active) protein (Fc Tag)IGF2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Insulin-Like Growth Factor 2 (IGF2) (AA 30-180), (partial) protein (GST tag)IGF2 Origin: Human Host: Escherichia coli (E. coli) Recombinant 90 % SDS, ELISA
Insulin-Like Growth Factor 2 (IGF2) (AA 25-91) (Active) protein (AVI tag,Fc Tag,Biotin)IGF2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 5 mM Hac, pH ~3.0.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- IGF2 (Insulin-Like Growth Factor 2 (IGF2))
- Alternative Name
- IGF-II/IGF2 (IGF2 Products)
- Background
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Background: Insulin-Like Growth Factor II (IGF2) belongs to the insulin family of polypeptide growth factors that is involved in development and growth. Members of this family are structurally homologous to proinsulin, and share higher sequence identity. IGF2 is expressed only from the paternally inherited allele and believed to be secreted by the liver and to circulate in the blood. IGF2 possess growth-promoting activity and can stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGF2 is influenced by placental lactogen and may play a role in fetal development.
Synonym: Insulin-Like Growth Factor II, IGF-II, Somatomedin-A, IGF2, PP1446
- Molecular Weight
- 8.9 kDa
- UniProt
- P01344
- Pathways
- Hormone Activity, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Activated T Cell Proliferation
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