Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

IDO1 Protein

IDO1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % as determined by reducing SDS-PAGE. Active
Catalog No. ABIN7196174
  • Target See all IDO1 Proteins
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 9
    • 4
    • 1
    Human
    Source
    • 7
    • 2
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human IDO1/IDO Protein (Active)
    Sequence
    Ala2-Gly403
    Characteristics
    A DNA sequence encoding the human IDO1 (NP_002155.1) (Ala2-Gly403) was expressed and purified with one additional amino acids (Gly) at the N-terminus.
    Purity
    > 85 % as determined by reducing SDS-PAGE.
    Biological Activity Comment
    Measured by its ability to oxidize L-tryptophan to N-formylk-ynurenine.The specific activity is > 500 pmoles/min/μg.
    Top Product
    Discover our top product IDO1 Protein
  • Restrictions
    For Research Use only
  • Format
    Frozen, Liquid
    Buffer
    Supplied as sterile 50 mM NaAC, 100 mM Nacl, 20 % glycerol, pH 5.5.
    Storage
    -20 °C
    Storage Comment
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Alternative Name
    IDO1/IDO (IDO1 Products)
    Synonyms
    INDO Protein, ido Protein, indo Protein, IDO Protein, cd107b Protein, IDO1 Protein, IDO-1 Protein, Ido Protein, Indo Protein, indoleamine 2,3-dioxygenase 1 Protein, indoleamine 2,3-dioxygenase 1 L homeolog Protein, indoleamine 2,3-dioxygenase 1-like Protein, IDO1 Protein, ido1.L Protein, ido1 Protein, Ido1 Protein, LOC100050681 Protein
    Background

    Background: Indoleamine 2,3-dioxygenase-1, also known as Indoleamine-pyrrole 2,3-dioxygenase, IDO1 and IDO, is a member of the indoleamine 2,3-dioxygenase family. IDO1 / IDO and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that catalyze the first step in tryptophan catabolism via the kynurenine pathway. TDO is widely distributed in both eukaryotes and bacteria. In contrast, IDO has been found only in mammals and yeast. In 2007, a third enzyme, indoleamine 2,3-dioxygenase-2 (IDO2), was discovered. IDO2 is found not only in mammals but also in lower vertebrates. IDO1 / IDO is an immunosuppressive molecule inducible in various cells. IDO1 / IDO catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. It mediates oxidative cleavage of tryptophan, an amino acid essential for cell proliferation and survival. IDO1 / IDO inhibition is proposed to have therapeutic potential in immunodeficiency-associated abnormalities, including cancer. The IDO pathway is activated in multiple tumor types. Selective inhibition of IDO1 may represent an attractive cancer therapeutic strategy via up-regulation of cellular immunity. IDO1 / IDO is an enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular microenvironment. Inhibition of IDO pathway might enhance the efficacy of immunotherapeutic strategies for cancer.Immune CheckpointImmune Checkpoint Detection: ELISA AntibodiesCo-inhibitory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Synonym: Indole 2;3-dioxygenase; Indoleamine 2;3-dioxygenase 1; IDO-1; IDO1; IDO; INDO

    Molecular Weight
    45.2 kDa
    NCBI Accession
    NP_002155
    Pathways
    Activated T Cell Proliferation
You are here:
Support