HOXB4 Protein (His tag)

Catalog No. ABIN7319405

Product Details

Target: HOXB4 (Homeobox B4 (HOXB4))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This HOXB4 protein is labelled with His tag.

Purpose: Recombinant Human HOXB4 Protein (His Tag)

Sequence: Met1-Leu251

Characteristics: Recombinant Human Homeobox protein B4 is produced by our E.coli expression system and the target gene encoding Met1-Leu251 is expressed with a 6His tag at the N-terminus.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 4 mM HCl.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: HOXB4 (Homeobox B4 (HOXB4))

Alternative Name: HOXB4 (HOXB4 Products)

Synonyms: HOX-2.6 Protein, HOX2 Protein, HOX2F Protein, Hox-2.6 Protein, Chox-Z Protein, hox2 Protein, hox2f Protein, hox-2.6 Protein, XHox-b4 Protein, HOX-B4 Protein, Z-17 Protein, ZF-13 Protein, hoxb4 Protein, zf13 Protein, Hoxb4 Protein, RGD1560113 Protein, HOXB4 Protein, FrHOXB-4 Protein, HoxB4a Protein, homeobox B4 Protein, homeobox B4 S homeolog Protein, homeobox B4a Protein, hox4 protein Protein, homeo box B4 Protein, hoxb4a protein Protein, HOXB4 Protein, Hoxb4 Protein, hoxb4 Protein, hoxb4.S Protein, hoxb4a Protein, hox4 Protein

Background:

Background: Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

Synonym: Homeobox protein Hox-B4, Homeobox protein Hox-2.6, Homeobox protein Hox-2F, HOXB4, HOX2F

Molecular Weight: 29.8 kDa

UniProt: P17483