HNMT Protein (GST tag)

Catalog No. ABIN7196099

Product Details

Target: HNMT (Histamine N-Methyltransferase (HNMT))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This HNMT protein is labelled with GST tag.

Purpose: Recombinant Human HNMT Protein (GST Tag)

Sequence: Met 1-Ala 292

Characteristics: A DNA sequence encoding the human HNMT (AAH20677.1) (Met 1-Ala 292) was fused with the GST tag at the N-terminus.

Purity: > 85 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 0.15M NaCl, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: HNMT (Histamine N-Methyltransferase (HNMT))

Alternative Name: HNMT (HNMT Products)

Synonyms: HMT Protein, HNMT-S1 Protein, HNMT-S2 Protein, hmt Protein, hnmt Protein, hnmt-s1 Protein, hnmt-s2 Protein, zgc:100917 Protein, HNMT Protein, 1500031F01Rik Protein, AI788969 Protein, HMT A Protein, hnmt-a Protein, hnmt-b Protein, histamine N-methyltransferase Protein, histamine N-methyltransferase S homeolog Protein, histamine N-methyltransferase-like Protein, histamine N-methyltransferase L homeolog Protein, HNMT Protein, hnmt.S Protein, hnmt Protein, Hnmt Protein, LOC100228106 Protein, hnmt.L Protein

Background:

Background: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin, the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin, it is imperative to determine the nature of the activin/follistatin binding complex.

Synonym: HMT,HNMT-S1,HNMT-S2

Molecular Weight: 60.5 kDa