HMOX1 Protein

Catalog No. ABIN7318568

Product Details

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human HO-1/HMOX1 Protein

Sequence: Met 1-Thr 261

Characteristics: Recombinant Human Heme Oxygenase 1 is produced by our E.coli expression system and the target gene encoding Met1-Thr261 is expressed.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Alternative Name: HO-1/HMOX1 (HMOX1 Products)

Synonyms: HMOX1 Protein, ARABIDOPSIS THALIANA HEME OXYGENASE 1 Protein, ATHO1 Protein, F18A8.4 Protein, F18A8_4 Protein, GENOMES UNCOUPLED 2 Protein, GUN2 Protein, HEME OXYGENASE Protein, HEME OXYGENASE 1 Protein, HEME OXYGENASE 6 Protein, HO1 Protein, HY1 Protein, HY6 Protein, PLASTID HEME OXYGENASE Protein, REVERSAL OF THE DET PHENOTYPE 4 Protein, HO-1 Protein, wu:fc27c04 Protein, zgc:65984 Protein, D8Wsu38e Protein, Hemox Protein, Hmox Protein, Hsp32 Protein, HEOXG Protein, Heox Protein, Ho-1 Protein, Ho1 Protein, hsp32 Protein, MGC132176 Protein, Hmox1 Protein, HMOX1D Protein, HSP32 Protein, bK286B10 Protein, heme oxygenase 1 Protein, Plant heme oxygenase (decyclizing) family protein Protein, Heme oxygenase Protein, heme oxygenase Protein, heme oxygenase 1, chloroplastic Protein, heme oxygenase 1a Protein, heme oxygenase 1 L homeolog Protein, HMOX1 Protein, TED4 Protein, ho1 Protein, P9301_RS17555 Protein, A9601_RS17590 Protein, MAE_RS06565 Protein, HO1 Protein, hmox1a Protein, CPE0214 Protein, Cyan7425_2962 Protein, Hmox1 Protein, hmox1.L Protein, AM1_C0205 Protein, CC1G_11686 Protein, CpipJ_CPIJ007246 Protein

Background:

Background: Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.

Synonym: Heme Oxygenase 1, HO-1, HMOX1, HO, HO1

Molecular Weight: 29.9 kDa

UniProt: P09601

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome