GBP1 Protein (His tag)
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- Target See all GBP1 Proteins
- GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This GBP1 protein is labelled with His tag.
- Purpose
- Recombinant Human GBP1 Protein (His Tag)
- Sequence
- Met 1-Cys 589
- Characteristics
- A DNA sequence encoding the human GBP1 (AAA35871.1) (Met 1-Cys 589) was fused with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product GBP1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))
- Alternative Name
- GBP1 (GBP1 Products)
- Synonyms
- guanylate binding protein 1 Protein, guanylate binding protein 1, interferon-inducible Protein, guanylate binding protein 1, interferon-inducible, 67kD Protein, GBP1 Protein, Gbp1 Protein, gbp1 Protein
- Background
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Background: Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1β (IL-1β), IL-1α, and tumor necrosis factor-α (TNF-α). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secretion occurred without the presence of a leader peptide. Secretion procession is a nonclassical, likely ABC transporter-dependent, pathway and independent of GBP-1 GTPase activity and isoprenylation, and did not require additional interferon-λ-induced factors. Clinically most important was the detection of significantly increased GBP-1 concentrations in the cerebrospinal fluid of patients with bacterial meningitis as compared to control patients.
Synonym: GBP1
- Molecular Weight
- 69 kDa
- Pathways
- Cellular Response to Molecule of Bacterial Origin
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