Growth Hormone Receptor Protein (GHR) (Fc Tag)
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- Target See all Growth Hormone Receptor (GHR) Proteins
- Growth Hormone Receptor (GHR)
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Human Cells
- Purification tag / Conjugate
- This Growth Hormone Receptor protein is labelled with Fc Tag.
- Purpose
- Recombinant Mouse Growth Hormone Receptor/GHR Protein (Fc Tag)
- Sequence
- Met1-Gln273
- Characteristics
- Recombinant Mouse Growth Hormone receptor is produced by our Mammalian expression system and the target gene encoding Met1-Gln273 is expressed with a Fc tag at the C-terminus.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product GHR Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Growth Hormone Receptor (GHR)
- Alternative Name
- Growth Hormone Receptor/GHR (GHR Products)
- Synonyms
- GHBP Protein, AA986417 Protein, GHR/BP Protein, GHR Protein, ghr Protein, ghr.a Protein, zgc:162141 Protein, growth hormone receptor Protein, growth hormone receptor L homeolog Protein, growth hormone receptor a Protein, GHR Protein, Ghr Protein, ghr.L Protein, ghr Protein, ghra Protein
- Background
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Background: Growth hormone receptor is a transmembrane receptor for growth hormone (GH). GH is a single-chain polypeptide that is mainly synthesized and released from the anterior pituitary gland and plays essential roles in growth, development and metabolism. GH exerts its physiological actions via GH binding to its receptor in its extracellular domain. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Growth hormone receptor has been shown to interact with SGTA, PTPN11, Janus kinase 2, Suppressor of cytokine signaling 1 and CISH.
Synonym: growth hormone binding protein, growth hormone receptor, serum binding protein, Somatotropin receptor,GHR, GH receptor, GHBP
- Molecular Weight
- 58.3 kDa
- UniProt
- Q3UP14
- Pathways
- NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus
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