Growth Hormone 1 Protein (GH1)

Catalog No. ABIN7196005

Product Details

Target: Growth Hormone 1 (GH1)

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human GH1/Growth hormone 1 Protein (Active)

Sequence: Phe27-Phe217

Characteristics: A DNA sequence encoding the human GH1 (P01241) (Phe27-Phe217) was expressed.

Purity: > 90 % as determined by reducing SDS-PAGE.

Biological Activity Comment: Measured by its ability to promote proliferation of INS-1 cells.The ED50 for this effect is 0.2-1 ng/mL.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Growth Hormone 1 (GH1)

Alternative Name: GH1/Growth hormone 1 (GH1 Products)

Background:

Background: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.

Synonym: GH,GH-N,GH1,GHB5,GHN,Growth hormone 1,hGH-N,IGHD1B

Molecular Weight: 22.1 kDa

UniProt: P01241

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process