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QPCT Protein (His tag)

QPCT Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7195939
  • Target See all QPCT Proteins
    QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))
    Protein Type
    Recombinant
    Origin
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 6
    • 2
    • 2
    • 1
    • 1
    Baculovirus infected Insect Cells
    Purification tag / Conjugate
    This QPCT protein is labelled with His tag.
    Purpose
    Recombinant Human Glutaminyl cyclase/QPCT Protein (His Tag)
    Sequence
    Ala33-Leu361
    Characteristics
    A DNA sequence encoding the human QPCT (Q16769-1) (Ala33-Leu361) was fused with a polyhistide tag at the N-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product QPCT Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))
    Alternative Name
    Glutaminyl cyclase/QPCT (QPCT Products)
    Synonyms
    GCT Protein, QC Protein, sQC Protein, QPCT Protein, 5730422A13Rik Protein, Qpctl1 Protein, RGD1562284 Protein, qpct Protein, glutaminyl-peptide cyclotransferase Protein, glutaminyl-peptide cyclotransferase (glutaminyl cyclase) Protein, glutaminyl-peptide cyclotransferase L homeolog Protein, QPCT Protein, Qpct Protein, M6_Spy0443 Protein, M5005_Spy_0416 Protein, M28_Spy0404 Protein, CJA_2408 Protein, CCNA_02733 Protein, Tsp_03182 Protein, qpct.L Protein
    Background

    Background: Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate(pGlu). The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioactive peptides, while the aberrant formation of pGlu may be related to several pathological processes, such as osteoporosis and amyloidotic diseases. Glutaminyl cyclase's structure reveals an alpha/beta scaffold akin to that of two-zinc exopeptidases but with several insertions and deletions, particularly in the active-site region. Glutaminyl cyclase's amino acid sequence of this enzyme is 86 % identical to that of bovine glutaminyl cyclase. It is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides.

    Synonym: GCT,QC,sQC

    Molecular Weight
    39.7 kDa
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