FZD10 Protein (His tag)
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- Target See all FZD10 Proteins
- FZD10 (Frizzled Family Receptor 10 (FZD10))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FZD10 protein is labelled with His tag.
- Purpose
- Recombinant Human Frizzled-10/FZD10 Protein (His Tag)
- Sequence
- Met 1-Gly161
- Characteristics
- A DNA sequence encoding the human FZD10 (NP_009128.1) (Met1-Gly161) was expressed with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product FZD10 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- FZD10 (Frizzled Family Receptor 10 (FZD10))
- Alternative Name
- Frizzled-10/FZD10 (FZD10 Products)
- Synonyms
- CD350 Protein, FZ-10 Protein, Fz10 Protein, FzE7 Protein, hFz10 Protein, cFz-10 Protein, Fz-10 Protein, Xfr9 Protein, Xfz10 Protein, frizzled-10 Protein, frizzled10 Protein, fz10 Protein, fze7 Protein, hfz10 Protein, fk48e04 Protein, fz4 Protein, fzb Protein, wu:fk48e04 Protein, zg04 Protein, Xfz10A Protein, fzd10a Protein, Xfz10B Protein, Xfz9 Protein, fzd10b Protein, fzd9 Protein, frizzled class receptor 10 Protein, frizzled class receptor 10 L homeolog Protein, frizzled class receptor 10 S homeolog Protein, FZD10 Protein, fzd10 Protein, Fzd10 Protein, fzd10.L Protein, fzd10.S Protein
- Background
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Background: Frizzled-10, also known as Fz-10, CD350 and FZD10, is a multi-pass membrane protein which belongs to the G-protein coupled receptor Fz/Smo family. Frizzled-10 / FZD10 is abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. It is weakly expressed in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. Frizzled-10 / FZD10 is a receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Frizzled-10 / FZD10 may also be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Synonym: CD350;FZ-10;Fz10;FzE7;hFz10
- Molecular Weight
- 17.5 kDa
- NCBI Accession
- NP_009128
- Pathways
- WNT Signaling
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