ESAM Protein

Catalog No. ABIN7317973

Product Details

Target: ESAM (Endothelial Cell Adhesion Molecule (ESAM))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purpose: Recombinant Human ESAM Protein

Sequence: Met 1-Ala 248

Characteristics: The mature form of human ESAM (NP_620411.2) extracellular domain (Met 1-Ala 248) with five amino acids (DDDDK) at the C-terminus was expressed and purified.

Purity: > 92 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 100 mM NaCl, 50 mM Tris, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ESAM (Endothelial Cell Adhesion Molecule (ESAM))

Alternative Name: ESAM (ESAM Products)

Synonyms: ESAM Protein, sc:d0254 Protein, W117m Protein, 2310008D05Rik Protein, Esam1 Protein, endothelial cell adhesion molecule Protein, endothelial cell adhesion molecule a Protein, endothelial cell-specific adhesion molecule Protein, ESAM Protein, esama Protein, Esam Protein

Background:

Background: Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.

Synonym: W117m

Molecular Weight: 24.5 kDa

NCBI Accession: NP_620411