Dual Specificity Phosphatase 3 (DUSP3) protein (His tag)
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- Target See all Dual Specificity Phosphatase 3 (DUSP3) Proteins
- Dual Specificity Phosphatase 3 (DUSP3)
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- His tag
- Purpose
- Recombinant Human DUSP3/VHR Protein (His Tag)
- Sequence
- Ser2-Pro185
- Characteristics
- Recombinant Human DUSP3 is produced by our E.coli expression system and the target gene encoding Ser2-Pro185 is expressed with a 6His tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product DUSP3 Protein
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- Dual Specificity Phosphatase 3 (DUSP3)
- Alternative Name
- DUSP3/VHR (DUSP3 Products)
- Synonyms
- dusp3 Protein, si:bz18k17.3 Protein, si:rp71-18k17.3 Protein, VHR Protein, RGD1560049 Protein, 2210015O03Rik Protein, 5031436O03Rik Protein, T-DSP11 Protein, dual specificity phosphatase 3 Protein, dual specificity phosphatase 3b Protein, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) Protein, DUSP3 Protein, dusp3b Protein, Dusp3 Protein
- Target Type
- Viral Protein
- Background
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Background: Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively regulate members of the mitogen-activated protein kinase superfamily, which are associated with cellular proliferation and differentiation. DUSP3 is expressed in human tissues including breast and ovarian.DUSP3 shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Human DUSP3 specifically dephosphorylates and inactivates ERK1 and ERK2.
Synonym: Dual specificity protein phosphatase 3,DUSP3,Dual specificity protein phosphatase VHR,Vaccinia H1-related phosphatase,VHR
- Molecular Weight
- 22.6 kDa
- UniProt
- P51452
- Pathways
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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