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Desmocollin 2 Protein (DSC2) (His tag)

DSC2 Origin: Human Host: HEK-293 Cells Recombinant > 75 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7317758
  • Target See all Desmocollin 2 (DSC2) Proteins
    Desmocollin 2 (DSC2)
    Protein Type
    Recombinant
    Origin
    Human
    Source
    • 3
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Desmocollin 2 protein is labelled with His tag.
    Purpose
    Recombinant Human DSC2/Desmocollin-2 Protein (His Tag)
    Sequence
    Met 1-Arg 684
    Characteristics
    A DNA sequence encoding the extracellular domain (Met 1-Arg 684) of human DSC2 (Q02487-1) was expressed, with a C-terminal polyhistidine tag.
    Purity
    > 75 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product DSC2 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Desmocollin 2 (DSC2)
    Alternative Name
    DSC2/Desmocollin-2 (DSC2 Products)
    Synonyms
    ARVD11 Protein, CDHF2 Protein, DG2 Protein, DGII/III Protein, DSC3 Protein, AW228162 Protein, Dsc2a Protein, Dsc2b Protein, DSC2 Protein, desmocollin 2 Protein, DSC2 Protein, Dsc2 Protein
    Background

    Background: DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in DSC2 are associated with arrhythmogenic right ventricular dysplasia-11. DSC2 is Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms.

    Synonym: ARVD11,CDHF2,DG2,DGII/III,DSC3

    Molecular Weight
    75 kDa
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