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DEFB4A Protein

DEFB4 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7319217
  • Target See all DEFB4A (DEFB4) Proteins
    DEFB4A (DEFB4) (Defensin, beta 4A (DEFB4))
    Protein Type
    Recombinant
    Origin
    • 3
    • 1
    • 1
    Human
    Source
    • 3
    • 2
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human β-Defensin 4A/DEFB4A Protein
    Sequence
    Gly24-Pro64
    Characteristics
    Recombinant Human beta-Defensin 4A is produced by our E.coli expression system and the target gene encoding Gly24-Pro64 is expressed.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product DEFB4 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 130 mM NaCl, pH 7.4.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    DEFB4A (DEFB4) (Defensin, beta 4A (DEFB4))
    Alternative Name
    beta-Defensin 4A/DEFB4A (DEFB4 Products)
    Synonyms
    BD-2 Protein, DEFB-2 Protein, DEFB102 Protein, DEFB2 Protein, DEFB4 Protein, HBD-2 Protein, SAP1 Protein, BD2 Protein, DEFB4P Protein, THP2 Protein, defensin beta 4A Protein, defensin beta 2 Protein, defensin beta 1 Protein, avian beta-defensin 4 Protein, defensin, beta 4A Protein, beta-defensin 2 Protein, defensin beta 4 Protein, beta defensin 2 Protein, DEFB4A Protein, Defb2 Protein, DEFB1 Protein, AvBD4 Protein, THP2 Protein, defb4 Protein, SBD2 Protein
    Background

    Background: β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38 % and 33 % amino acid sequence identity with mouse and rat BD3, respectively.

    Synonym: Beta-Defensin 4A, Beta-Defensin 2, BD-2, hBD-2, Defensin, Beta 2, Skin-Antimicrobial Peptide 1, SAP1, DEFB4A, DEFB102, DEFB2, DEFB4, DEFB4B

    Molecular Weight
    4.3 kDa
    UniProt
    O15263
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