beta Defensin 1 Protein

Catalog No. ABIN7319215

Product Details

Target: beta Defensin 1 (DEFB1) (Defensin, beta 1 (DEFB1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human β-Defensin 1/DEFB1 Protein

Sequence: Gly22-Lys68

Characteristics: Recombinant Human beta-Defensin 1 is produced by our E.coli expression system and the target gene encoding Gly22-Lys68 is expressed.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 130 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: beta Defensin 1 (DEFB1) (Defensin, beta 1 (DEFB1))

Alternative Name: beta-Defensin 1/DEFB1 (DEFB1 Products)

Synonyms: BD1 Protein, DEFB-1 Protein, DEFB101 Protein, HBD1 Protein, AW260221 Protein, BD-1 Protein, DEFB1-like Protein, RHBD-1 Protein, CBD1 Protein, PBD-1 Protein, DEFB1 Protein, BNBD-1 Protein, defensin beta 1 Protein, avian beta-defensin 1 Protein, defensin, beta 1 Protein, beta-defensin 1-like Protein, beta-defensin 1 Protein, DEFB1 Protein, Defb1 Protein, AvBD1 Protein, LOC100861170 Protein

Background:

Background: β-Defensin 1 (DEFB1) is a member of the β-defensin family, which is highly expressed by epithelial cells. β-defensins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal peptide. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensin 1 is an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. Defects in β-Defensin-1 contribute to asthma diagnosis, with apparent gender-specific effects in human. β-defensin 1 may also play a role in the pathogenesis of severe sepsis. In addition, β-defensin 1 is associated with induction profiles in gingival keratinocytes.

Synonym: Beta-Defensin 1, BD-1, hBD-1, Defensin Beta 1, DEFB1, BD1, HBD1

Molecular Weight: 5.1 kDa

UniProt: P60022