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CST7 Protein

CST7 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7195341
  • Target See all CST7 Proteins
    CST7 (Cystatin F (Leukocystatin) (CST7))
    Protein Type
    Recombinant
    Origin
    • 7
    • 4
    Human
    Source
    • 5
    • 3
    • 2
    • 1
    HEK-293 Cells
    Purpose
    Recombinant Human Cystatin 7/CST7 Protein
    Sequence
    Met 1-His 145
    Characteristics
    The mature form of the human Cystatin F (NP_003641.3) (Met 1-His 145) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
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    Discover our top product CST7 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CST7 (Cystatin F (Leukocystatin) (CST7))
    Alternative Name
    Cystatin 7/CST7 (CST7 Products)
    Synonyms
    CST7 Protein, LOC100232568 Protein, cytf Protein, CMAP Protein, Cmap Protein, cystatin F Protein, Cystatin F Protein, cystatin F (leukocystatin) Protein, CST7 Protein, cytf Protein, Cst7 Protein
    Background

    Background: The cystatin superfamily members are important natural cysteine protease inhibitors present in a wide variety of organisms and are divided into three classes. Cystatin F, also known as leukocystatin and CMAP (Cystatin-like Metastasis-Associated Protein), is a type 2 cystatin and its expression is limited to hematopoietic cells, with the highest expression levels being observed in monocytes, dendritic cells, and certain types of T-cells. Furthermore, cystatin F mRNA becomes up-regulated during dendritic cell maturation, and thus suggests a specific role of cystatin F in immune regulation. Cystatin F is produced as a dimer, an inactive cathepsin inhibitor which is activated by chemical reduction. In addition, Cystatin F and its homologues have been observed expressing in various human cancer cell lines established from malignant tumors, and thus indicates a new diagnosis and prevention approach of certain human carcinomas metastasis.

    Synonym: Cystatin-F, Cystatin-7, Cystatin-Like Metastasis-Associated Protein, CMAP, Leukocystatin, CST7

    Molecular Weight
    15.2 kDa
    NCBI Accession
    NP_003641
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