CDK2AP2 Protein (His tag)
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- Target See all CDK2AP2 Proteins
- CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CDK2AP2 protein is labelled with His tag.
- Purpose
- Recombinant Human CDK2AP2 Protein (E.coli, His Tag)
- Sequence
- Met 1-Thr 126
- Characteristics
- A DNA sequence encoding the human CDK2AP2 (O75956) (Met 1-Thr 126) was fused with a polyhistidine tag at the C-terminus.
- Purity
- > 78 %(the upper band)+17 %(the lower band) as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CDK2AP2 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, 15 % glycerol, pH 7.5
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2))
- Alternative Name
- CDK2AP2 (CDK2AP2 Products)
- Synonyms
- DOC-1R Protein, p14 Protein, zgc:92182 Protein, 5830466O21Rik Protein, D19Ertd144e Protein, Doc-1r Protein, cyclin dependent kinase 2 associated protein 2 Protein, cyclin-dependent kinase 2 associated protein 2 Protein, CDK2-associated protein 2 Protein, CDK2AP2 Protein, cdk2ap2 Protein, Cdk2ap2 Protein
- Background
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Background: CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative last exons and 4 validated alternative polyadenylation sites. The mRNAs appear to differ splicing versus retention of 3 introns. CDK2AP2 plays a role in regulating self-renewal of mouse embryonic stem cells (mESC) under permissive conditions, and cell survival during differentiation of the mESC into terminally differentiated cell types.
Synonym: Cyclin-dependent kinase 2-associated protein 2,CDK2-associated protein 2,DOC-1-related protein,DOC-1R,CDK2AP2,DOC1R,p14
- Molecular Weight
- 14.5 kDa
- UniProt
- O75956
- Pathways
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
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