Contactin 4 Protein (CNTN4) (His tag)

Catalog No. ABIN7317984

Product Details

Target: Contactin 4 (CNTN4)

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This Contactin 4 protein is labelled with His tag.

Purpose: Recombinant Human Contactin 4/CNTN4 Protein (His Tag)

Sequence: Met 1-Ser 1000

Characteristics: A DNA sequence encoding the mature form of human CNTN4 isoform 1 (Q8IWV2-1) (Met 1-Ser 1000) was fused with a polyhistidine tag at the C-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.5, 10 % gly

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Contactin 4 (CNTN4)

Alternative Name: Contactin 4/CNTN4 (CNTN4 Products)

Synonyms: Axcam Protein, Big-2 Protein, AXCAM Protein, BIG-2 Protein, 9630050B05 Protein, FAR-1 Protein, MGC84491 Protein, zgc:153573 Protein, axcam Protein, big-2 Protein, cntn4a Protein, contactin 4 Protein, contactin 4 S homeolog Protein, Cntn4 Protein, CNTN4 Protein, cntn4.S Protein, cntn4 Protein

Background:

Background: Contactin-4, abbreviated as CNTN4, is a brain-derived protein belonging to the immunoglobulin superfamily. It has been found high expression in testes, thyroid, small intestine, uterus and brain. This protein is an neuronal membrane protein that functions as an glycosylphosphatidylinositol- anchored cell adhesion molecule. Contactin-4 is considered as a candidate protein responsible for the differentiation potential of human neuroblastoma cells and it has been implicated in some cases of autism and spinocerebellar ataxia type 16. Studies of the cantactin family have revealed a complex pattern of hemophilic and heterophilic interactions that are required for axon growth and pathfinding. Such studies demonstrate that these essential functions are mediated by the combination and juxtaposition of multiple Ig and FNIII domains. Second, these neuronal adhesion molecules demonstrate highly regulated temporal and spatial expression patterns in the CNS. For this reason, the disruption of the regulatory region of the predominant brain-expressed isoform reasonable would be expected to have significant functional consequences. 

Synonym: AXCAM;BIG-2

Molecular Weight: 110 kDa