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CPLX2 Protein (His tag)

CPLX2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7317462
  • Target See all CPLX2 Proteins
    CPLX2 (Complexin 2 (CPLX2))
    Protein Type
    Recombinant
    Origin
    • 4
    • 2
    • 1
    • 1
    Human
    Source
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This CPLX2 protein is labelled with His tag.
    Purpose
    Recombinant Human Complexin-2/CPLX2 Protein (His Tag)
    Sequence
    Asp 2-Lys 134
    Characteristics
    A DNA sequence encoding the human CPLX2 (Q6PUV4-1) (Asp 2-Lys 134) was expressed, with a polyhistide tag at the N-terminus.
    Purity
    > 90 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product CPLX2 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CPLX2 (Complexin 2 (CPLX2))
    Alternative Name
    Complexin-2/CPLX2 (CPLX2 Products)
    Synonyms
    921-L Protein, CPX-2 Protein, CPX2 Protein, Hfb1 Protein, AI413745 Protein, AW492120 Protein, MGC68923 Protein, MGC79539 Protein, complexin 2 Protein, complexin 2 L homeolog Protein, complexin-2 Protein, CPLX2 Protein, Cplx2 Protein, cplx2.L Protein, cplx2 Protein, LOC750228 Protein
    Background

    Background: Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Complexins are unable to bind to monomeric SNARE proteins but bind with high affinity to ternary SNARE complexes and with lower affinity to target SNARE complexes. Complexin 1 (CX1) and complexin 2 (CX2) are presynaptic proteins that modulate neurotransmitter release and are used as markers of inhibitory and excitatory synapses, respectively. CPLX2 is localized in pre-synaptic terminals in mature brain. The G71-P89 region of CPLX2 is essential and sufficient for preferential axonal distribution. CPLX2 participates in the Ca(2+)-sensitive regulatory pathway for zymogen granule exocytosis. Complexin-2 is a key player in normal neurological function, and its downregulation could lead to changes in neurotransmitter release sufficient to cause significant behavioural abnormalities such as depression. It is involved in synaptogenesis and the modulation of neurotransmitter release.

    Synonym: 921-L,CPX-2,CPX2,Hfb1

    Molecular Weight
    16.8 kDa
    Pathways
    Synaptic Vesicle Exocytosis
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