C3 Protein

Catalog No. ABIN7318326

Product Details

Target: C3 (Complement Component 3 (C3))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human Complement Component C3a/C3a Protein

Sequence: Ser672-Arg748

Characteristics: Recombinant Human Complement Component C3a is produced by our E.coli expression system and the target gene encoding Ser672-Arg748 is expressed.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: C3 (Complement Component 3 (C3))

Alternative Name: Complement Component C3a/C3a (C3 Products)

Synonyms: AHUS5 Protein, ARMD9 Protein, ASP Protein, C3a Protein, C3b Protein, CPAMD1 Protein, AI255234 Protein, HSE-MSF Protein, Plp Protein, C3 Protein, C3-1 Protein, sb:cb26 Protein, si:dkey-76b14.4 Protein, wu:fi34b03 Protein, wu:fj86e11 Protein, C3d Protein, asp Protein, cpamd1 Protein, c3 Protein, complement C3 Protein, complement component 3 Protein, complement component c3a, duplicate 1 Protein, complement component 3 L homeolog Protein, complement component C3 Protein, complement C3-like Protein, C3 Protein, c3a.1 Protein, c3.L Protein, LOC443475 Protein, c3 Protein, c3-1 Protein, LOC100060539 Protein

Background:

Background: Complement is defined as key part of innate immunity and as the first line of defense in the fight against invading pathogens. Complement 3 (C3) is the most abundant component of the complement cascade and the convergent point for all three major complement activation pathways: namely classical, alternative and mannose-binding lectin pathways. Complement activation leads to the formation of the C3 convertase, which cleaves C3 into the key effector molecules, C3a (anaphylatoxin) and C3b (opsonin) which then drive microbe removal. By binding to C3a receptor (C3aR), C3a exhibits potent anaphylatoxin activity, including increased vascular permeability, triggering degranulation of mast cells, inflammation, and activating leukocytes.

Synonym: Complement Component C3a, C3a, Anaphylatoxin

Molecular Weight: 9.1 kDa

UniProt: P01024

Pathways: Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling