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CNTF Protein

CNTF Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Catalog No. ABIN7319650
  • Target See all CNTF Proteins
    CNTF (Ciliary Neurotrophic Factor (CNTF))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 15
    • 8
    • 3
    • 2
    • 2
    • 2
    Human
    Source
    • 22
    • 3
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human CNTF Protein (Active)
    Sequence
    Ala2-Met200
    Characteristics
    Recombinant Human Ciliary Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala2-Met200 is expressed.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 25 ng/ml.
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    Discover our top product CNTF Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS,1 mM Cysteine,PH7.4.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CNTF (Ciliary Neurotrophic Factor (CNTF))
    Alternative Name
    CNTF (CNTF Products)
    Synonyms
    GPA Protein, CNTF Protein, HCNTF Protein, AI429687 Protein, ciliary neurotrophic factor Protein, CNTF Protein, Cntf Protein
    Background

    Background: Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83 % homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.

    Synonym: Ciliary Neurotrophic Factor, CNTF

    Molecular Weight
    22.93 kDa
    UniProt
    P26441
    Pathways
    JAK-STAT Signaling
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