CMA1 Protein (His tag)
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- Target See all CMA1 Proteins
- CMA1 (Chymase 1, Mast Cell (CMA1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This CMA1 protein is labelled with His tag.
- Purpose
- Recombinant Human CMA1/Chymase 1 Protein (His Tag)
- Sequence
- Met 1-Asn 247
- Characteristics
- A DNA sequence encoding the human CMA1 (P23946) (Met 1-Asn 247) was fused with a polyhistidine tag at the C-terminus.
- Purity
- > 92 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product CMA1 Protein
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- CMA1 (Chymase 1, Mast Cell (CMA1))
- Alternative Name
- CMA1/Chymase 1 (CMA1 Products)
- Synonyms
- CYH Protein, MCT1 Protein, chymase Protein, MMCP-5 Protein, Mcp-5 Protein, Mcp5 Protein, Mcpt5 Protein, MCP3P Protein, CMA1 Protein, Chymase Protein, chymase 1 Protein, chymase 1, mast cell Protein, chymase-like Protein, CMA1 Protein, Cma1 Protein, LOC100008644 Protein
- Background
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Background: Chymotrypsin C (abbreviated for CTRC), also known as caldecrin or elastase4, is a digestive enzyme of the peptidase S1 family. This enzyme is synthesized as an inactivate chymotrypsinogen. On cleavage by trypsin into two parts that activate each other by removing two small peptides in a trans-proteolysis, chymotrypsin C produced. N-linked glycosylation of human CTRC is required for efficient folding and secretion, however, the N-linked glycan is unimportant for enzyme activity or inhibitor binding. It has been proposed that CTRC is a key regulator of digestive zymogen activation and a physiological co-activator of digestive carboxypeptidases proCPA1 and proCPA2. Mutations that abolish activity or secretion of CTRC increase the risk for chronic pancreatitis. It's speculated that CTRC might regulate pancreatic cancer cell migration in relation to cytokeratin 18 expression. The pancreatic cancer cell migration ability was downregulated in pancreatic cancer Aspc-1 cells that overexpressed CTRC, whereas the cell migration ability was upregulated in Aspc-1 cells in which CTRC was suppressed.
Synonym: chymase;CYH;MCT1
- Molecular Weight
- 26.6 kDa
- UniProt
- P23946
- Pathways
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis
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